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1: Nature. 2001 Feb 15;409(6822):832-3.
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Expressing the human genome.

Tupler R, Perini G, Green MR.

Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester 01605, USA.

We have searched the human genome for genes encoding new proteins that may be involved in three nuclear gene expression processes: transcription, pre-messenger RNA splicing and polyadenylation. A plethora of potential new factors are implicated by sequence in nuclear gene expression, revealing a substantial but selective increase in complexity compared with Drosophila melanogaster and Caenorhabditis elegans. Although the raw genomic information has limitations, its availability offers new experimental approaches for studying gene expression.

Publication Types:
PMID: 11237001 [PubMed - indexed for MEDLINE]