Table 1

Mutated viral strain analysis. Percentages of viral strain carrying the rtM204V/I or the rtN236T mutation determined with in-house selective real-time PCR (ARMS).
Date
 Treatment
 HBV viral load (log IU/mL)
 % rtM204 (wt)
 % rtM204V
 % rtM204I
 % rtN236 (wt)
 % rtN236T
M0
 LMV
 8.6
 100
 0
 0
 -
 -
M3
 LMV
 5.2
 100
 0
 0
 -
 -
M7
 LMV
 6.1
 28
 48
 24
 -
 -
M10
 LMV
 8.1
 34
 45
 21
 -
 -
M12
 LMV
 8.6
 22
 58
 20
 -
 -
M14
 LMV
 8.8
 30
 50
 20
 -
 -
M16
 LMV + ADV
 5.9
 8
 67
 25
 -
 -
M19
 LMV + ADV
 5.2
 37
 43
 20
 -
 -
M22
 LMV + ADV
 4.8
 24
 51
 25
 -
 -
M24
 LMV + ADV
 4.6
 26
 49
 25
 -
 -
M27
 LMV + ADV
 4.1
 66
 19
 15
 -
 -
M30
 LMV + ADV
 4.2
 66
 22
 12
 -
 -
M36
 ADV
 3.3
 83
 7
 10
 100
 0
M39
 ADV
 3.3
 74
 8
 18
 100
 0
M42
 ADV
 2.6
 75
 8
 17
 96
 4
M46
 ADV
 3.4
 82
 8
 10
 79
 21
M48
 ADV
 4.1
 98
 2
 0
 66
 34
M51
 LMV + ADV
 3.0
 87
 0
 13
 71
 29
M55
 LMV + ADV
 2.9
 86
 14
 0
 73
 27

Note: wt = wild type, -: not done

Larrat et al. Comparative Hepatology 2008 7:3   doi:10.1186/1476-5926-7-3