Figure 3.

Expression of AFP gene and Rev-Erb A, Rev-Erb B and N-CoR in liver regeneration with 2-AAF treatment. After partial hepatectomy in 2-AAF treated rats, the expression of the AFP gene (A) and of Rev-Erb A, Rev-Erb B and N-CoR (B) were measured by real-time PCR. The mean values and the standard deviations of two different series are demonstrated. At day 7, the full-length AFP-RNA (AFP1) is maximally increased. The smaller variants of AFP-RNA (AFP2) showed no significant changes. Four days after the maximum increase of the full-length AFP-RNA Rev-Erb A is maximally decreased. Rev-Erb B is slightly decreased at each time point. N-CoR shows only slight changes in this model.