This article is part of the supplement: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells

Proceedings

Thioredoxin prevents thioacetamide-induced acute hepatitis

Hiroaki Okuyama¹ , Yasuyuki Shimahara¹ , Hajime Nakamura² , Shinichi Araya² , Norifumi Kawada³ , Yoshio Yamaoka³ and Junji Yodoi²

¹Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, Japan

²Department of Biological Responses, Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University; Shogoin, Kawahara-cho, Sakyo-ku, Kyoto, Japan 606-8397

³Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan

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Comparative Hepatology 2004, 3(Suppl 1):S6doi:10.1186/1476-5926-2-S1-S6

Published:	14 January 2004

First paragraph (this article has no abstract)

Thioredoxin (Trx) is an endogenous multifunctional protein with a redox-active disulfide/dithiol within the conserved active site sequence: -Cys-Gly-Pro-Cys- [1]. Trx is also a stress-inducible protein whose expression is enhanced by various types of stresses, e.g., viral infection, exposure to UV light, x-ray irradiation, and hydrogen peroxide (H₂O₂) [2]. Furthermore, Trx is a scavenger of reactive oxygen species (ROS), and recombinant Trx has protective activity against ROS-mediated cytotoxicity [3]. We have previously reported that Trx attenuates an ischemic brain damage by scavenging radicals [4].