This article is part of the supplement: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells . ProceedingsIntralobular Distribution of Vitamin A-Storing Lipid Droplets in Hepatic Stellate Cells with Special Reference to Polar Bear and Arctic FoxNobuyo Higashi1 1 Department of Anatomy, Akita University School of Medicine, Akita 010-8543, Japan 2 Liver Research Unit, Minophagen Pharmaceutical Co. Ltd., Tokyo 160-0004, Japan 3 Institute for Nutrition Research, Faculty of Medicine, University of Oslo, Norway 4 Division of Molecular Biology, Institute of Biology, University of Oslo, Norway 5 Electronmicroscopical Unit for Biological Sciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Norway
Comparative Hepatology 2004, 3(Suppl 1):S16doi:10.1186/1476-5926-2-S1-S16
AbstractWe examined the liver of adult polar bears, arctic foxes, and rats by gold chloride staining, fluorescence microscopy for the detection of autofluorescence of vitamin A, hematoxylin-eosin staining, staining with Masson's trichrome, Ishii and Ishii's silver impregnation, and transmission electron microscopical morphometry. The liver lobules of the arctic animals showed a zonal gradient in the storage of vitamin A. The density (i.e., cell number per area) of hepatic stellate cells was essentially the same among the zones. These results indicate that the hepatic stellate cells of the polar bears and arctic foxes possess heterogeneity of vitamin A-storing capacity in their liver lobules. |
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