Table 4

Integrated database, with predictive values for the diagnosis of significant necroinflammatory hepatic activity according to METAVIR conversion cut offs. Derived from published studies.
Integrated database
 Patient number
 Marker
 Grade/Prevalence
 AUROC (SE)
 Cut off used for METAVIR stages conversion
 Sensitivity
 Specificity
 Negative predictive value
 Positive predictive value
With Blood Donors
 1,570
 ActiTest
 A2A3/0.41
 0.85 (0.01)
 0.17
 0.95
 0.55
 0.94
 0.60





0.29
 0.87
 0.69
 0.88
 0.66





0.36
 0.81
 0.74
 0.85
 0.69





0.52
 0.62
 0.86
 0.76
 0.75





0.60
 0.51
 0.90
 0.72
 0.77





0.61
 0.50
 0.90
 0.72
 0.78





0.62
 0.49
 0.91
 0.72
 0.78
Without blood donors
 1,270
 ActiTest
 A2A3/0.51
 0.78 (0.01)
 0.17
 0.95
 0.40
 0.89
 0.62





0.29
 0.87
 0.55
 0.80
 0.67





0.36
 0.81
 0.63
 0.76
 0.69





0.52
 0.62
 0.79
 0.67
 0.75





0.60
 0.51
 0.85
 0.63
 0.77





0.61
 0.50
 0.85
 0.62
 0.78





0.62
 0.49
 0.86
 0.62
 0.78

Poynard et al. Comparative Hepatology 2004 3:8   doi:10.1186/1476-5926-3-8