Table 2

Integrated database, with predictive values for significant hepatic fibrosis according to METAVIR conversion cut offs. Derived from published studies.
Integrated database
 Patient number
 Marker
 Stage/Prevalence
 AUROC (SE)
 Cut off used for METAVIR stages conversion
 Sensitivity
 Specificity
 Negative predictive value
 Positive predictive value
With Blood Donors
 1,570
 FibroTest
 F2F3F4/0.31
 0.83 (0.01)
 0.21
 0.92
 0.55
 0.94
 0.48





0.27
 0.87
 0.62
 0.92
 0.51





0.31
 0.84
 0.68
 0.91
 0.54





0.48
 0.68
 0.81
 0.85
 0.61





0.58
 0.56
 0.87
 0.82
 0.67





0.72
 0.38
 0.95
 0.77
 0.76





0.74
 0.35
 0.95
 0.76
 0.76





0.75
 0.33
 0.96
 0.76
 0.78
Without blood donors
 1,270
 FibroTest
 F2F3F4/0.38
 0.78 (0.01)
 0.21
 0.92
 0.41
 0.89
 0.49





0.27
 0.87
 0.48
 0.86
 0.51





0.31
 0.84
 0.55
 0.85
 0.54





0.48
 0.68
 0.73
 0.79
 0.61





0.58
 0.56
 0.83
 0.75
 0.67





0.72
 0.38
 0.95
 0.70
 0.76





0.74
 0.35
 0.93
 0.70
 0.76





0.75
 0.33
 0.94
 0.69
 0.78

Poynard et al. Comparative Hepatology 2004 3:8   doi:10.1186/1476-5926-3-8