Table 1

Summary of the diagnostic value of FibroTest for the staging of hepatic fibrosis and comparisons with hyaluronic acid, the Forns Index and the APRI Index in patients with chronic hepatitis C, from the published studies.
First author
 N*
 Methodology
 Marker
 Stage/Prevalence
 AUROC SE
 Cut off
 Sensitivity
 Specificity
Imbert-Bismut, 2001
 189
 Prospective
Single center
First year cohort
 FibroTest
 F2F3F4 / 0.38
 0.84 (0.03)
 0.10
0.30
0.60
0.80
 0.97
0.79
0.51
0.29
 0.24
0.65
0.94
0.95
Imbert-Bismut, 2001
 134
 Prospective
Single center
Validation cohort
 FibroTest
 F2F3F4 / 0.45
 0.87 (0.03)
 0.10
0.30
0.60
0.80
 1.00
0.87
0.70
0.38
 0.22
0.59
0.95
0.97
Poynard, 2001
 165
 Retrospective
Randomized trial
Multicenter
 FibroTest
 F3F4 Knodell / 0.32
 0.74 (0.03)
 0.10
0.30
0.60
0.80
 0.96
0.81
0.50
0.13
 0.24
0.65
0.92
0.98
Poynard, 2001
 165
 Retrospective
Randomized trial
Multicenter
 Hyaluronic
 F3F4 Knodell / 0.32
 0.65 (0.03)
 20
40
100
 0.81
0.47
0.23
 0.39
0.65
0.91
Poynard, 2003
 352
 Retrospective
Randomized trial
Multicenter
Before treatment
 FibroTest
 F2F3F4 / 0.39
 0.73 (0.03)
 0.10
0.30
0.60
0.80
 0.97
0.86
0.50
0.20
 0.08
0.45
0.79
0.95
Poynard, 2003
 352
 Retrospective
Randomized trial
Multicenter
After treatment
 FibroTest
 F2F3F4 / 0.32
 0.77 (0.03)
 0.10
0.30
0.60
0.80
 0.98
0.85
0.46
0.16
 0.15
0.39
0.81
0.97
Rossi, 2003
 125
 Prospective
Multicenter
Non-validated analyzers
 FibroTest
 F2F3F4 / 0.38
 0.74 (0.05)
 0.10
0.30
0.60
0.80
 0.92
0.75
0.42
0.22
 0.29
0.61
0.94
0.96
Myers, 2003
 130
 Retrospective
Single center
HCV-HIV Co-infection
 FibroTest
 F2F3F4 / 0.45
 0.86 (0.04)
 0.10
0.30
0.60
0.80
 0.98
0.90
0.66
0.34
 0.17
0.60
0.92
0.96
Thabut, 2003
 249
 Retrospective
Single center
From Imbert-Bismut, 2001
 FibroTest
 F2F3F4 / 0.38
 0.84 (0.02)
 0.10
0.30
0.60
0.80
 0.98
0.84
0.58
0.29
 0.22
0.65
0.93
0.95
Thabut, 2003
 249
 Retrospective
Single center
From Imbert-Bismut, 2001
 Forns Index
 F2F3F4 / 0.38
 0.78 (0.03)
 1
3
6
8
 1.00
1.00
0.55
0.19
 0.04
0.26
0.86
0.97
Le Calvez, 2004
 323
 Retrospective
Single center
From Imbert-Bismut, 2001
 FibroTest
 F2F3F4 / 0.41
 0.83 (0.02)
 0.10
0.30
0.60
0.80
 0.97
0.81
0.58
0.33
 0.30
0.66
0.93
0.95
Le Calvez, 2004
 323
 Retrospective
Single center
From Imbert-Bismut, 2001
 APRI Index
 F2F3F4 / 0.41
 0.74 (0.03)
 0.50
1.00
1.50
2.00
 0.81
0.54
0.36
0.24
 0.56
0.84
0.91
0.95
Callewaert, 2004
 82
 Prospective
 FibroTest
 F4 / 0.29
 0.89 (0.04)
 0.10
0.30
0.60
0.80
 1.00
0.92
0.79
0.67
 0.33
0.62
0.81
0.92
Callewaert, 2004
 82
 Prospective
 Glyco Cirrho Test
 F4 ** / 0.29
 0.87 (0.04)
 -0.2
0.1
0.4
0.6
 1.00
0.79
0.21
0.17
 0.12
0.88
0.95
1.00

* Number of patients. ** Compensated

Poynard et al. Comparative Hepatology 2004 3:8   doi:10.1186/1476-5926-3-8