Table 4

Hepatic GSH levels after treatment with Pb(NO3)2, GdCl3 or with 24 hours pretreatment of GdCl3 before exposure to Pb(NO3)2 .*
Weeks
 Untreated / BSO
 PbNO3
 GdCl3
 GdCl3 / PbNO3


3 days
 5 days
 3 days
 5 days
 3 days
 5 days
-
 29.00





1
 17.76 {- 3%}
 13.80
 11.02
 14.05
 16.03
 16.03
 18.09
2
 9.65 {- 47%}
 8.50
 5.70
 8.90
 11.02
 6.20
 10.10
3
 5.09 {- 72%}
 6.65
 4.30
 6.42
 7.90
 6.10
 8.80

* GSH values are given as nmol / mg protein. Animals were fed with 2 mM BSO for 1, 2 or 3 weeks before injection with the different heavy metals, and the GSH content was evaluated at 3 and 5 days after the injection. Standard deviations did not exceed 5%. In brackets is the percentage of decrement of GSH levels relative to control untreated animals. Each value is the mean of 3 independent experiments, using 3 different animals.

Pagliara et al. Comparative Hepatology 2003 2:8   doi:10.1186/1476-5926-2-8