|
GSH/GSSG levels in hepatocytes after in vivo treatment with Pb(NO3)2, GdCl3 or with 24 hours pretreatment of GdCl3 before exposure to Pb(NO3)2.* |
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| Days |
Untreated |
PbNO3 |
GdCl3 |
GdCl3/PbNO3 |
|
|
||||
| 16.05/0.20 {3} |
||||
| 1 |
13.34/2.93 {3} |
14.90/6.29 {2} |
8.15/2.35 {2} |
|
| 3 |
3.20/2.13 {10} |
5.86/5.39 {10} |
11.23/2.83 {6} |
|
| 5 |
3.49/1.36 {39} |
5.90/3.43 {15} |
10.24/6.11 {18} |
|
| 15 |
2.74/0.64 {20} |
10.18/0.61 {10} |
10.18/6.61 {10} |
|
|
* The values are given as total glutathione intracellular GSH/GSSG nmol/mg protein. The relative apoptotic percentages are reported in square brackets. Standard deviations did not exceed 5%. For each point 4 animals have been used. | ||||
Pagliara et al. Comparative Hepatology 2003 2:8 doi:10.1186/1476-5926-2-8 |
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