Figure 1.

Schematic representation of the hypothalamus-pituitary-gonadal-liver (HPGL) axis during oogenic protein synthesis in female teleosts. The HPGL is regulated through the negative feedback mechanism by estradiol-17β. The hypothamalus, pituitary, gonad and liver are all potential targets for endocrine disruptors, as discussed in the text. GtH = gonadotropin I & II.